Progesterone Receptor

NR3C3

Progesterone Receptor

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Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

Progesterone Receptor Related Products (159)
Recombinant Proteins (1)
Antibodies (2)

By Effects:	Inhibitors (11) Agonists (76) Ligands (5) Antagonists (22) Activators (10) Modulators (10)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-119482

Cymipristone	Antagonist
Cymipristone (ZXH-951), a progesterone receptor antagonist, is used potentially for termination of intrauterine pregnancy.

HY-B0648S1

Medroxyprogesterone-d₇	Agonist
Medroxyprogesterone-d₇ is deuterium labeled Medroxyprogesterone.

HY-B0257AS

Dydrogesterone-d₆	Agonist
Dydrogesterone-d₆ is the deuterium labeled Dydrogesterone. Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.

HY-13676S1

Megestrol acetate-d₃-1	Inhibitor
Megestrol acetate-d₃-1 is deuterium labeled Megestrol acetate. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway.

HY-B0521S

Altrenogest-d₅	Agonist
Altrenogest-d₅ is the deuterium labeled Altrenogest. Altrenogest (Allyltrenbolone) is a progestogen structurally related to veterinary steroid trenbolone.

HY-W753897

Gestodene-d₇
Gestodene-d₇ is the deuterium labeled Gestodene (HY-B0110). Gestodene is a progestin-based contraceptive. Gestodene is a click chemistry reagent. It contains an alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an azide group.

HY-106297

Tosagestin
Tosagestin(Org 30659) is a 19-nortestosterone–derived progestagen. Tosagestinsuppresses ovarian function to a level sufficient to inhibit ovulation. Tosagestininhibits cell growth in T47D-S cells.

HY-B0469S1

Medroxyprogesterone acetate-d₇
Medroxyprogesterone acetate-d₇ (Medroxyprogesterone 17-acetate-d₇) is the deuterium labeled Medroxyprogesterone acetate (HY-B0469) . Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.

HY-16483

Telapristone acetate	Modulator
Telapristone acetate (CDB-4124) is a potent progesterone receptor (PR) modulator. Telapristone acetate inhibits the proliferation of ovarian cancer cells by inducing cell cycle arrest and apoptosis. Telapristone effectively inhibits the occurrence and development of spontaneous and chemically induced mammary tumors in rats. Telapristone acetate can be used for breast and ovarian cancer research.

HY-B1095S2

Chlormadinone acetate-d₃	Agonist
Chlormadinone acetate-d₃ is the deuterium labeled Chlormadinone acetate (HY-B1095). Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders.

HY-106751

Anordrin	Inhibitor
Anordrin is a contraceptive agent. Anordrin exhibits estrogenicites and can induce decrease in serum progesterone levels in rat models. Anordrin inhibits endometrial epithelial cell mitosis and NAFLD induced by Tamoxifen (HY-13757A) in mouse uterus and liver as an anti-estrogenic and estrogenic agent.

HY-B0110S

Gestodene-d₆	Agonist
Gestodene-d₆is the deuterium labeled Gestodene. Gestodene(SHB 331) is a progestogen hormonal contraceptive. Gestodene-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-113889

ZK112993	Antagonist
ZK112993 is a potent progesterone receptor (PR) antagonist. ZK112993 significantly inhibits the growth of T61 human tumors in nude mice.

HY-16290

Lonaprisan	Antagonist
Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC₅₀ of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect.

HY-B0652R

Etonogestrel (Standard)	Agonist
Etonogestrel (Standard) is the analytical standard of Etonogestrel. This product is intended for research and analytical applications. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs. Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs).

HY-B0652S1

Etonogestrel-d₆	Agonist
Etonogestrel-d₆ is deuterium labeled Etonogestrel. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs. Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs).

HY-133007

Algestone acetophenide		99.36%
Algestone acetophenide is a progesterone drug. Algestone acetophenide can be used in combination with estrogen as a long-acting injectable contraceptive.

HY-N0437F

Progesterone 3-biotin	Ligand
Progesterone 3-biotin (Pregn-4-ene-3,20-dione-biotin) is a biotin-labeled probe that allows progesterone to be detected or immobilized using the biotin ligand. Progesterone 3-biotin is the biotinylated derivative of Progesterone (HY-N0437).

HY-A0285R

Norethisterone enanthate (Standard)
Norethisterone enanthate (Standard) is the analytical standard of Norethisterone enanthate. This product is intended for research and analytical applications. Norethisterone enanthate is a long-acting parenteral progestogen. Norethisterone enanthate is orally active. Norethisterone enanthate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W753635

EC 313	Modulator
EC 313 is a selective progesterone receptor modulator. EC 313 can dose dependently reduce the weight of fibroids. EC 313 can reduce the expression of ER and PR. EC 313 can be used for the study of uterine fibroids.

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Progesterone Receptor

Progesterone Receptor

Progesterone Receptor Related Products (159)

Recombinant Proteins (1)

Antibodies (2)

Progesterone Receptor Related Products (159):